Fisayo Dele-Bashiru scored his first Serie A goal as Lazio extended their unbeaten run in all competitions to seven.
The Super Eagles midfielder came on as a second half substitute to register his first league goal for the club.
Dele-Bashiru on the 85th minute for Argentine forward Taty Castellanos and made an impact moments later.
The 23-year-old latched on to a miscued pass from Isaksen and buried the ball into the net to wrap up a brilliant performance from the home side.
Fisayo Dele-Bashiru joined Lazio on loan from Turkish side Hatayspor during the summer transfer window.
The Italian club has an obligation to buy the midfielder at the end of the season for an agreed price.
Fisayo Dele-Bashiru is a Manchester City academy player. He featured for the under 18 and 23 teams before he joined Sheffield Wednesday in 2021.
Lazio’s 3-0 victory over Bologna at the Stadio Olimpico on Sunday night extended their unbeaten run to seven matches across all competitions.